Acute Results of the Restenosis Reduction by Cutting Balloon Evaluation
Study R Prpic*, T Suzuki, J J Popma, H
Hosokawa, T Yamaguchi, S Ito, H Oda, T Kondo, T Matsushita, K Kanemasa, M
Adams, T Fukutomi, Brigham and Women's Hospital, Boston, MA,
USA Background: The REstenosis ReDUction by Cutting
Balloon Evaluation (REDUCE) Study is
a prospective multicenter (44 Japanese sites) registry to assess the efficacy
of Cutting Balloon (CB) angioplasty. Methods: Quantitative
coronary angiography (QCA) was performed on a total of 570 patients, who had
been randomly assigned to either CB or conventional balloon angioplasty (PTCA). Results: Procedural
success was higher with CB than PTCA (94.7% vs 88.6%, p<0.01). The incidence
of coronary dissections and bail-out stenting was also significantly lower in
the CB group (24% vs 32%, p=0.028; 5% vs 11%, p=0.003). Balloon size (3.34 vs
3.27mm), number of inflations (3.0 vs 3.0) and balloon to artery ratio (1.08 vs
1.09) were similar in both groups, however maximum inflation pressure was lower
with CB than PTCA (7.1 vs 10.2 ATM, p<0.0001). QCA
Results CB
(n=280) PTCA
(n=290) p-value Ref
D (mm) 2.9
± 0.5 3.0
± 0.5 ns MLD
pre (mm) 1.1
± 0.3 1.1
± 0.4 ns MLD
post (mm) 2.1
± 0.4 2.1
± 0.4 ns %DS
pre 62
± 10 62
± 11 ns %DS
post 27
± 9 28
± 8 ns Ref D = reference diameter, MLD = minimal lumen diameter, %DS = percent diameter stenosis Conclusion: An optimal
angiographic result is obtained using the Cutting Balloon with lower inflation
pressures than PTCA, potentially reducing the degree of arterial trauma.
Cutting Balloon use resulted in a lower incidence of dissections and bail-out
stenting than conventional PTCA.
