RPAH Cardiovascular Genetics Future Leader Fellowship – Sydney, NSW

Position: RPAH Cardiovascular Genetics Future Leader Fellowship

Overview of Research

Major advances have been made in defining the genetic basis of cardiovascular diseases, including the inherited heart muscle problems (cardiomyopathies) and the primary electrical (arrhythmogenic) disorders. The most tragic and devastating complication of many of these genetic heart diseases is sudden cardiac death in the young. While there has been significant progress, many questions remain unanswered. In most of the genetic heart diseases, a genetic cause is not identified in up to 50% of patients. Furthermore, in those where a genetic cause has been identified, how these gene variants lead to clinical disease remain unclear. Our world-class research focuses on the identification of new genetic causes of disease in families with genetic heart diseases, elucidation of the underlying molecular mechanisms in how these diseases develop, and application of this new knowledge in the clinical setting to improve diagnosis and management. Using an integrated, state-of-the-art approach of clinical and genetic human studies, and patient-derived cell culture models, it is expected that new genetic knowledge, and translation of these findings to enhance diagnostic and therapeutic approaches, will lead to improved care of families with genetic heart diseases and prevention of sudden cardiac death, particularly in the young.

RPAH Cardiovascular Genetics Future Leader Fellowship

The inaugural recipient of this 2-year fellowship (total $200,000) will be an early career female researcher who is within 8 years post-PhD. The fellowship will be open to motivated cardiology trainees, basic scientists, and clinical researchers with the over-arching goal to develop as future leaders in the field of Genetic Heart Diseases. The fellowship will provide opportunities to undertake clinical and genetic research both at the Genetic Heart Disease Clinic program at RPAH, and at the Agnes Ginges Centre for Molecular Cardiology at the Centenary Institute. Both the clinic program and research centre were established, and are led by, Prof Chris Semsarian, who will also provide structured mentorship and guidance. The Fellowship will provide opportunities to present research at major national and international meetings, with the goal to develop true world leaders in the field of Genetic Heart Diseases.

For more details, contact:

Prof Chris Semsarian, AM, MBBS PhD MPH Cardiologist, Royal Prince Alfred Hospital (RPAH), USYD, Centenary Institute Email: c.semsarian@centenary.org.au

ANZCDACC Product Defect Correction Notification April 2022

ANZCDACC Product Defect Correction Notification

Device:

Merlin™ Patient Care System (PCS) Software Model 3330 v25.0.X–v25.3.X

GTIN 05414734509725

When used with

Abbott Gallant™, Neutrino™ NxT, Entrant™ devices

Note:

  1. In Australia; Neutrino™ NxT and Entrant ™ are currently approved but not commercially launched (Only Gallant is commercially available).
  2. In New Zealand; Only Gallant and Entrant are Medsafe WAND notified however only Entrant has been commercially launched at limited accounts.

 TGA Reference:

Australian Register of Therapeutic Goods (ARTG):

124262

Advisory grade TGA:

Class II

Class II- A situation in which use of, or exposure to, the deficient therapeutic good(s) may cause temporary or medically reversible adverse health consequences, or where the probability of serious adverse health consequences is remote.

ANZCDACC Product Defect Correction and Implant Hazard Alert June 2021

ANZCDACC Product Defect Correction and Implant Hazard Alert June 2021

Device: Medtronic Reveal LINQ with TruRhythm Cardiac Monitoring Systems

 TGA Reference: RC-2021-RN-01276-1

Australian Register of Therapeutic Goods (ARTG): 218791

Advisory grade TGA: Class II

(Class II recall action occurs when the product deficiency could cause illness, injury or result in mistreatment, but are not class I.)

ANZDACC Advisory Grade: Routine

ANZCDACC Safety Alert Notice March 21st 2021

ANZCDACC Safety Alert Notice March 21st 2021

Device:

Subset Biontronik Ilesto, Inventra, Iperia, Itrevia, Ilivia, Intica, Intica Neo ICDs and CRT-D implanted since 2013

TGA Reference: RC-2021-RN-00667-1

Advisory grade TGA:  Class I

(Class I recall action occurs when the product deficiency is potentially life threatening or could cause serious risk to health)

ANZDACC Advisory Grade: Routine

Number of CIEDs affected in Australia and New Zealand:

Australia Approximately  2000

New Zealand Approximately 500

ANZCDACC Product Notification Notice 22nd November 2019
UPDATE: 4th of Feb 2021

ANZCDACC Product Notification Notice 22nd November 2019

UPDATE: 4th of Feb 2021 – Updated text in purple.

Device:

Product ARTG
Claria MRI™ CRT-Ds
280183; 280186 ; 281607; 281608
Amplia MRI™ CRT-Ds
280182; 280184 ; 281606
Compia MRI™ CRT-Ds
280181 ; 280185
Viva™ CRT-Ds
203210 ; 203211; 203212; 203840; 219221; 219222; 230204
Brava™ CRT-Ds
219220
Visia AF™ ICDs
280351; 280352; 280353
Visia AF MRI™ ICDs
280354; 280355; 282960; 282961
Evera™ ICDs
206324; 208024; 208025; 208026; 208027; 208028; 208029; 208030
Evera MRI™ ICDs
208030; 230019; 230020; 230021; 230022; 281609; 281610; 281611; 281612
Primo MRI™ ICDs
312640 ; 312641; 312642; 312643
Mirro MRI ™ ICDs
Not sold in Australia

TGA Reference: RC-2019-RN-01641-1

Advisory grade TGA: TBA

ANZDACC Advisory Grade: Routine

Number of CIEDs affected in Australia and New Zealand: TBA

ANZCDACC Product Notification Notice 22nd November 2019

ANZCDACC Product Notification Notice 22nd November 2019

Device:

Product ARTG
Claria MRI™ CRT-Ds
280183; 280186 ; 281607; 281608
Amplia MRI™ CRT-Ds
280182; 280184 ; 281606
Compia MRI™ CRT-Ds
280181 ; 280185
Viva™ CRT-Ds
203210 ; 203211; 203212; 203840; 219221; 219222; 230204
Brava™ CRT-Ds
219220
Visia AF™ ICDs
280351; 280352; 280353
Visia AF MRI™ ICDs
280354; 280355; 282960; 282961
Evera™ ICDs
206324; 208024; 208025; 208026; 208027; 208028; 208029; 208030
Evera MRI™ ICDs
208030; 230019; 230020; 230021; 230022; 281609; 281610; 281611; 281612
Primo MRI™ ICDs
312640 ; 312641; 312642; 312643
Mirro MRI ™ ICDs
Not sold in Australia